1).Portable fetal electrocardiography：Fetal hypoxemia during pregnancy could change the shape of the fetal electrocardiogram (ECG) waveform, particularly the relation of the PR to RR intervals, and elevation or depression of the ST segment. Technical systems have therefore been established to monitor the fetal ECG as an adjunct to continuous electronic fetal heart rate (FHR) monitoring. We developed a novel portable fetal ECG monitor based on covariance and phase-space methods. Non-invasive FHR monitoring using the fetal ECG signals as obtained from the maternal abdomen has several advantages compared to electronic FHR monitoring. Main advantage of this method is obtaining prolonged non-invasive recordings and early detection of potential fetal distress.
2).Protein Chips for Prediction of Pre-eclampsia and Premature Birth: We collaborate with BioIC company to make protein chips for prediction of pre-eclampsia and premature birth in a microfluidic protein chips device. This will be done in a cohort study and validated for better prevention of pre-eclampsia and premature birth.
3).Developmental origin of health and disease (DOHaD): We collaborate with Taiwan Society of DOHaD to study and investigate how environmental factors interact with genes in perinatal stage to prime for diseases in adults in order to prevent from asthma, obesity and hypertension in adults. Particularly, we are promoting public awareness of perinatal exposure to tobacco smoke, plasticizer and PM2.5 on childhood hazards and health.
4).A Simultaneous POCT of Penumonia and Sepsis: We collaborate with Taiwan Carbon Nano Technology Company to develop a unique point of care test (POCT) for biomarkers detection of pneumonia and sepsis simultaneously in order to prevent pneumonia and sepsis of children.
5).Applications of ucMSCs and Its Exosomes: In consideration of umbilical cord enriched mesenchymal stem cells (ucMSCs) suitable for applications for anti-inflammatory lungs and brain diseases in infants and gandparents with degenerative diseases. The obstetricians and pediatricians in Mackay Memorial Hospital have made good progress on preparations of exosomes derived from ucMSCs for anti-inflammatory diseases and anti-degenerative diseases in animal models. We have filed 2 patents in regard to applications of ucMSCs for better anti-inflammatory and anti-cancer diagnosis and treatment. The progress and further studies might make our progress on preparations of ucMSCs and its exosomes for anti-inflammatory and anti-cancer precision medicine in 3 generations (grandchildren, parents and grandparents).
Cooperation projects and needs
1.Distribution channel- agents, distributors, or brokers on real-time monitoring & analysis system of fetal ECG