The Development of Microbubbles-based Medical Combination Products Combined with Ultrasound for Treating Ear Disease and Head and Neck Cancers
(1) Middle-ear dexamethasone delivery via ultrasound microbubbles attenuates noise-induced hearing loss.
(2) Poloxamer gel microbubbles can effectively achieve delayed delivery and controlled release of drugs in the inner ear.
(3) Ultrasound-induced microbubble cavitation via a transcanal or transcranial approach facilitates inner ear drug delivery.
(4) Ultrastructural changes associated with the enhanced permeability of the round window membrane mediated by ultrasound microbubbles.
(5) Insonation of systemically delivered cisplatin-loaded microbubbles significantly attenuates nephrotoxicity of chemotherapy in experimental models of head and neck cancer.
(6) Synergistic effects of combined treatment with ultrasound-mediated cisplatin-loaded microbubbles and atorvastatin on head and neck cancer.