Industrial Technology Research Institute (ITRI)

ITRI designed the “2030 Technology Strategy and Roadmap” and focuses its R&D efforts in three major areas: Smart Living, Quality Health, and Sustainable Environment. In the field of Quality Health R&D, ITRI leverages Taiwan's ICT industries and medical system features to further develop smart health care and medicine. ITRI’s scope of development includes medicine and diagnosis and treatment technologies in precision medicine, regenerative medicine, smart diagnosis and treatment imaging systems, digital health care services, medical image analysis, smart medical supplies, and smart bio-signal sensors. By integrating hard and software and generating medical service solutions, ITRI can facilitate the development of high level medical and high-quality health care service industries.

InnoCare Optoelectronics Corp.

X Ray Detector

Innovation Materials co., Ltd

醫療不織布材料，過濾不織布材料，口罩不織布材料，熱成型不織布材料，生物可分解性不織布材料

Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes

With the spread of coronavirus disease in 2019 worldwide in only two months, societies were significantly affected in many aspects, such as the economy, transportation, education, health infrastructure, and even the military. At present, the infection test is expensive and time-consuming, and cures are still under development. For the public, measuring forehead temperatures is a common method of identifying candidates for further investigation and treatment. As few confirmed cases have been reported in Taiwan, most schools remain open. To prevent disease transmission on campuses, the Ministry of Education has mandated daily temperature checks for everyone. Although such a check can be performed in seconds for an individual, large amounts of human resources are required to perform this task each day during the epidemic period. As a result, there is an urgent need to develop a suitable monitoring and management system. This developed thermal camera technology proposes a complete solution that includes cutting-edge artificial intelligence (AI) technology to meet this objective.

Institute of Cellular and Organismic Biology, Academia Sinica

Novel Anti-EpCAM Monoclonal Antibodies for the Development of Diagnostic and Therapeutic Applications

Institute of Genomics and Bioinformatics, National Chung Hsing University

Small-molecule stabilization of protein-protein interactions (PPIs) is a promising strategy in drug discovery. However, this approach has mainly focused on the stabilization of native PPIs, and non-native PPIs have received little consideration. Recently, a closely related novel coronavirus, SARS-CoV-2, caused an outbreak of pneumonia in the world. Here, we used the non-native dimer interface of the N-terminal domain (NTD) of N protein as the target in virtual screening for an orthosteric stabilizer. The interface formed a conserved hydrophobic cavity suitable for targeted drug screening. We found that a small molecule, P3, had both antiviral activities against CoVs and stabilizing effects on the viral N protein. Our results showed that P3 induces abnormal full-length N protein oligomerization in vitro and at the cell level. This conservation site may provide certain advantages when developing compounds with broad-spectrum activity against most CoVs, including SARS-CoV-2. This drug is able to relieve the clinical symptoms caused by a coronavirus in animal models. This unique approach based on the identification and stabilization of non-native PPIs of N protein could be applied toward drug discovery against CoV diseases.

Institute of Genomics and Bioinformatics, National Chung Hsing University

Small-molecule stabilization of protein-protein interactions (PPIs) is a promising strategy in drug discovery. However, this approach has mainly focused on the stabilization of native PPIs, and non-native PPIs have received little consideration. Recently, a closely related novel coronavirus, SARS-CoV-2, caused an outbreak of pneumonia in the world. Here, we used the non-native dimer interface of the N-terminal domain (NTD) of N protein as the target in virtual screening for an orthosteric stabilizer. The interface formed a conserved hydrophobic cavity suitable for targeted drug screening. We found that a small molecule, P3, had both antiviral activities against CoVs and stabilizing effects on the viral N protein. Our results showed that P3 induces abnormal full-length N protein oligomerization in vitro and at the cell level. This conservation site may provide certain advantages when developing compounds with broad-spectrum activity against most CoVs, including SARS-CoV-2. This drug is able to relieve the clinical symptoms caused by a coronavirus in animal models. This unique approach based on the identification and stabilization of non-native PPIs of N protein could be applied toward drug discovery against CoV diseases.

Institute of Molecular Biology, Academia Sinica/Research Team of Yu-Chan Chao Research Fellow

Our invention demonstrates an integrated platform for disease detection and vaccine production. It simultaneously provides detection products and vaccines for COVID-19. We engineered the insect baculovirus to display the SARS-CoV-2 spike and nucleocapsid proteins on the baculovirus envelope and the insect cell membrane. Cells displaying these two proteins become a novel COVID-19 serum detection system, and the baculoviruses displaying the proteins become the vector vaccines. In these processes, protein purification is unnecessary, thus significantly reducing the difficulty and cost of production. Moreover, baculovirus is highly safe for manufactures and users as it does not cause human infection. We also developed the immediate detection and prevention system for other emerging or recurring viruses. These developments are all important breakthroughs in fighting against viral diseases.

Institute of Nuclear Energy Research

HEXA-LACTOSIDE-TRIAZANONANE TRIACETIC ACID (NOTA) DERIVATIVE, METHOD FOR RADIOLABELING HEXA-LACTOSIDE POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AGENT FOR LIVER RECEPTOR WITH GA-68, AND HEXA-LACTOSIDE PET IMAGING AGENT FOR LIVER RECEPTOR

Institute of Physics, Academia Sinica

The SARS in 2003 and the Covid-19 pandemic in today raged the world. The body temperature monitoring became one of the most effective means to prevent the pandemic. The forehead infrared thermometer and infrared image camera came suddenly become the most effective tools for the pandemic. Up to now, forehead infrared thermometer has been popularly used because of its low price, however its disadvantage is that it takes time and man power to measure the body temperature one by one, and it is very inefficient and inconvenient. Although infrared image camera does not have the above shortcomings, unfortunately it is specially developed for military and national defense purposes based on high-resolution night vision images. Measuring body temperature is only one of the subsidiary functions. Since it is imported from abroad and with high resolution images thus the equipment used to measure body temperature is luxurious and not suitable. Its expensive price makes it difficult to be widely used. In order to overcome this problem, in 2007. my team started to develop an infrared image camera with main purpose of body temperature monitoring with image supplementation. Since it does not need to produce the equipment of defense-level high-resolution images, it can greatly reduce production costs. It can be accepted by the general public and will become an important tool against the Covid-19 epidemic.