National Chiao-Tung University / Assistant Professor Bor-Ran Li

There are approximately 20% population infertile in developed countries. Undeniably, the sperm quality dramatically influences on the embryo growth. It is essential to sort the sperms before assisted reproductive technologies performed. Nowadays, there are two common sorting methods in reproduction medical centers worldwide: swim-up and density-gradient centrifugation, DGC. However, the low-throughput and the sperm damage is still doubtable. Given that, our group developed a microfluidic technique for high-efficiency sperm sorting with advantages of low processing time, harmlessness and high purity of motile sperms. As proven, the percentage of motile sperms in the specimen of a severely-infertile patient was significantly increased from 2% to 97%, which was noticeably greater than that of swim-up (38%) and DGC (22%). Besides, immotile cells and debris were obviously removed. The sorted sperms can be further utilized to in vitro fertilization and/or intracytoplasmic sperm injection for successful fertilization and to fulfill the dream of infertile couples.

National Chung Cheng University

Hyperspectral imaging technology: Image identification and processing based on sample spectral characteristics, improving the problem of insufficient identification of traditional AOI technology.
The past technology is only based on the concept of color image processing technology. In this products, we break through the past image processing technology, through our Developed hyperspectral imaging technology. Through this technology, our method of analyzing images is based on the characteristics of the sample spectrum, and the image identification and processing. The characteristics of the sample spectrum can show the optical and material characteristics of the sample itself, which can solve the traditional technology. The problem of different object appearance and color characteristics is not obvious. In this products, we have combined this software technology with a hardware image sensor to create an innovative hyperspectral imager with a bandwidth of 380-780 nm, a resolution of 1 nm.

National Health Research Institutes / Dr. Min-Shi Lee

Influenza infections cause millions of hospitalisations and 300-650 thousand deaths annually. Vaccination is recommended to mitigate the disease burden. Egg-based vaccine production is a low-cost and mature platform and could supply seasonal influenza vaccines more than global demand. However, during the 2009 H1N1 influenza pandemic, the egg-based platform could provide only 20% of expected doses in the first 6 months. Therefore, it is desirable to develop multifunctional platforms for pandemic preparedness, which could be used to produce other human vaccines during inter-pandemic phases and converted to produce pandemic influenza vaccines during influenza pandemics. Vero cell-based platform could meet these criteria because it is used to produce several human vaccines. However, influenza viruses do not grow well in Vero cells. To improve the production efficiency of Vero cell-based influenza vaccines, we develop two Vero cell-derived master donor viruses to generate high-growth vaccine viruses for avian influenza H5N1, H5N2 and H7N9 viruses.

National Taiwan University of Science and Technology

With the spirit of "Practice-Oriented Education", Taiwan Tech is acknowledged as a top-tier technology university in Taiwan. It is home to provide innovative and key technologies to the global market. Taiwan Tech GLORIA has been supporting Taiwan Tech's research and to integrating industry-university-government high tech ecosystem under one roof to boost beneficially bilateral and multilateral cooperation in cutting edge technology fields. To capture the greatest values by participating in Taiwan Healthcare+ Expo, we've organized our strongest research delegation in Medical industry to display, including ring type and wrist-belt wearable devices, universal microbubbles based combined medical device for promoting local drug delivery, surface treatment for lubricity and non-stick medical tools, high sensitive electrical immunosensor, medical image and computer vision, motor control and motion analysis, multimedia big data, 3D medical image reconstruction, and so on.

National Tsing Hua University / Ultrasound Imaging Core Lab -Trust Bio-sonics

Current ultrasound contrast agents are made by phospholipid-shelled monolayer microbubbles. These bubbles have a very small particle size that could make them pass through the pulmonary system and circulate in the whole body. Based on the acoustic impedance mismatch, bubbles enhance the signal intensity of backscattered ultrasound helping physicians to clearly visualize small blood vessels in an ultrasound scanning.

After the six-year R & D, TRUST Bio-sonics (the spin-off company) has successfully identified the key factors to control the particle size of the bubble. Through precisely adjusting the lipid formulations, TRUST Bio-sonics commercialized the microbubble agent with the smallest particle sizes. This series of microbubbles contrast agent has the features of low risk of local embolism, high imaging resolution and high contrast enhancement of tumors. These characteristics assist physicians to collect detail perfusion information and practice quantitative diagnosis in a contrast-enhanced ultrasound imaging (CEUS). Now in Phase 1 trial (USFDA, TFDA).

NCKU / The team of Dr. CHUNYEN CHEN

本團隊以創新複合式微藻處理技術突破以往廢水處理中生物處理階段常遇到效果不彰之瓶頸，不僅可大幅改善動物飼養環境，且可有效降低廢水處理成本，友善鄰里，更可從中衍生出額外經濟效益，帶領一向被視為高污染之養豬產業升級。另外在工業廢水方面，則大幅節省用水量及降低污泥產生量，一樣能有效減少廢水處理費用，讓更多廠商願意確實投入廠內減廢，達到環境與利益兼具之雙贏局面。經過實證，利用本團隊開發之創新微藻廢水處理技術可有效將畜牧廢水中的COD、BOD、總氮及總磷在短期時間內降至放流水標準，可直接澆灌農田，或者經過簡單處理後用以清洗豬舍，而所生成之微藻藻體後續則可往飼料添加劑與有機肥料進行開發。在工業廢水方面，結果證實，本技術可有效處理異辛醇等石化廢水，兩天內便將1900 mg/L之COD值降至97 mg/L，達到放流水標準，且可有效處理高濃度異辛醇原廢水，COD去除效率有七成之高，顯現卓越處理效能，而生成之藻體將作為輔助性燃料增加燃燒熱值，也可往生質燃料進行開發，打造低排放甚至於零排放之永續環境，並貫徹我國「循環經濟」政策，提高經濟價值並達到永續經營之概念。
本團隊的創新微生物廢水處理技術，可有效淨化廢水，不但減少了廢水處理程序，需投入資金少、處理穩定性高、操作簡易，如此永續循環且親民的系統實為業界首創，與市場有高度區隔，因而具有獨佔性。全球養豬產業年產量達10億頭，估計市場達到5000億以上，而工業廢水處理市場更是龐大，預估已有2兆新台幣以上之規模。相信本團隊能以此創新廢水處理系統快速增加市場佔有率，初期目標以台灣為主，市場佔有率可達1-5%，而中長期目標期望能拓展至世界，預估總佔有率將提升至15%以上。而利用本處理技術淨化廢水的同時，轉化生成的藻體也可往具有高經濟價值微藻進行開發，包括了肥料、水產營養補充劑、生質燃料等，因此可大幅增加獲利空間，更有利於後續市場佔有率拓展。

NCKU / WJM team/JustWin bio-tech

We are committed to solving various diseases involved in the abnormal inflammatory response, and through the innovative anti-inflammatory strategy to build a comprehensive service platform, providing a series of technologies and products including drugs, testing and beauty care.

Plastics Industry Development Center

In order to assist plastics industry and accelerate the advancement of the plastics technology, Plastics Industry Development Center (PIDC) was established in 1993 and funded by the government and plastics industry.

Since 2000, PIDC has been working in the field of medical devices for many years, playing an important role in the development of polymeric medical devices in Taiwan. To accelerate medical devices innovation, we deliver below services:
◆ Medical device design and development
◆ Patent and industry analysis
◆ Process technology and supply chain integration
◆ Test verification service
◆ Quality system counseling
◆ License application counseling

PLUS ONE INNOVATION

1. Klebsiella pneumoniae serotype K1/K2 rapid testing cassette: published in SCI journals; used by the medical centers; 13th National Innovation Award in Taiwan; TFDA License No.007019.
2. Antibiotic testing and screening system: published in an SCI journal; used by pharmaceutical companies.
3. Diabetes candidate drug: control type 2 diabetes, atherosclerosis and body weight at the same time.
4. Natural food: Exquisite Ginger Tea; Natural Capsules.
5. Skin care: Purifying Hydration Mask.

RuiTai Medical Corp.

"Anatase" Spine Navigator
1. Cost-effective Image Construction
‒ Registration with preoperative CT imaging and familiar C-arm systems (only 2 X-rays images needed)
‒ Efficient alignment process in less than 5 minutes
‒ Significantly reduce harmful radiation exposure
2. Reliable Navigation
‒ Realize elaborative surgical procedure by planning
‒ Enhance surgery precision and efficiency with real-time navigation
‒ Elevate surgeons' confidence with intraoperative verification (Guide pin, Pedicle screw)
3. User-friendly Mechanism
‒ Non-contact device replacement procedures
‒ High compatible integration instruments