Taipei Veterans General Hospital Yuanshan Branch、National Taipei University of Technology

As Taiwan enters an aging society, the increase in the use of drips and urine bags will cause a large burden on medical staff. In response to this situation, this project developed a smart liquid level sensing device and smart monitoring system. The completed projects are as follows:

1.Develop mini liquid level measurement device and integrates low-power wireless communication system which send information to monitoring repeater.
2.Develop an APP to display the usage status of the device in real time through the account login interface, Integrate user\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\'s ID for uploading to cloud database, information shown on apps includes: conditions、device ID、liquid level、device mode and power.
3.Develop a cloud database with time record function, which can provide medical staff for follow-up data analysis based on historical records.
4. Develop a monitoring system APP, this system can obtain all device data from the cloud database.
5. Develop a dedicated APP, after logging in to the account, monitor the patient\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\'s drip and urine bag usage.

Using this system will effectively monitor and manage the drip and urine bag use of each patient, reduce the workload of medical staff, improve medical satisfaction, and improve medical-patient relationship and safety.

Taipei Veterans General Hospital, National Yang-ming University, National Chiao Tung University, Nat

Retinal diseases are the main cause of blindness, including senile retinal degeneration, diabetic retinopathy, and hereditary retinopathy. The angiogenesis of severe macular degeneration can only be treated with regular intraocular injection of anti-angiogenesis drugs, but it cannot be effectively treated. Luxturna, the first gene therapy drug, used an adenovirus-like virus that carried alleles to treat hereditary retinal disease-Lieber's Congenital Amaurosis (LCA). However, the efficacy of gene therapy with viral vectors cannot be sustained, and patients have to bear the risk of surgery repeatedly, which is the biggest disadvantage. CRISPR editing is the hope of treating retinopathy, but this novel technology is still a considerable challenge in retinal diseases. Nano-medicine-based nanoparticles can safely and effectively deliver the CRISPR-cas9 system, and repeat the treatment by intravitreal injection, which is a new treatment strategy.
This project combines leading nanoscience scholars and ophthalmologists to develop a precise nanogene therapy platform for hereditary retinopathy. It can be developed into a nanomedicine product with clinical application potential. It is expected that nano-gene therapy drugs can be successfully developed to build a basis for clinical trials in Taiwan and achieve the medical purpose of improving visual quality.

Taipei Veterans General Hospital/ National Yang-Ming University

Age-related macular degeneration exert impact on the vision of elderly people. The most problematic issue to treat AMD is the loss of retinal pigment epithelium (RPE) cells and the invasion of new blood vessels. To date, there is no clinically effective treatment, and RPE cells can be produced in vitro from mesenchymal stem cells, embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC). iPSC has attracted much attention due to its therapeutic potential. Although Japan has completed human trials of iPSC-RPE transplantation, it still cannot restore the eyesight of patients due to impaired Bruch’s membrane. We developed a biomimetic cell scaffold on polydimethylsiloxane (PDMS) as a repair material for Bruch's membrane, which can also be attached and grown by iPSC-derived RPE cells. We also introduced cylindrical micro-pillars into the back of the biological scaffold. It aims to provide high resistance to movement of tissue engineered RPE cell sheets grown on biological scaffolds. In order to prevent the invasion of new blood vessels, we have further established a drug slow-release coating on the stent, which can effectively inhibit angiogenesis. Based on the above advantages, the multifunctional implantable retinal bio-scaffold system developed has potential application in the treatment of wet AMD.

Taiwan Seed Improvement and Propagation Station, COA, ROC

A new hybrid, Dendrobium Taiseed Tosnobile(DTT), was derived from crossing and breeding between Dendrobium tosaense and Dendrobium nobile. The new hybrid has advantages of speedy growth while maintaining high concentration of effective ingredients. It has the scientific name given by the Royal Horticultural Society and the rights of the Republic of China. Previous studies have proven its safety for diet, as it passed acute and chronic toxicity tests, including 28-day and 90-day feeding toxicity, genotoxicity, and reproductive toxicity, and from which two SCI-indexed reports have been published. Since ancient Chinese medicine had described Dendrobium for vision protection, but without experimental evidence,
the effects of Dendrobium Taiseed Tosnobile extracts for alleviation of dry eye symptoms in an UVB-induced mouse model were investigated. Female ICR mice aged 6 weeks were randomly divided into 6 groups: vehicle control group, UVB-induced dry eye group, 3 experimental groups undertaken UVB irradiation and given extracts at 20、50、100 mg/Kg of body weight, and a group given 100 mg/Kg of body weight without UVB irradiation. The dietary feeding and UVB irradiation were given daily. One days 0, 4, 7, tear volume (TV) and tear film break up time (TBUT) were assessed and photography was taken on day 8 for evaluation of ocular surface damages, before the animals were sacrificed for histopathological analyses. The results showed that the status of ocular surface, TV and TBUT were dose-dependently improved. Histopathological analysis showed amelioration of damages to extra-lacrimal glands and meibomian glands. These results support and justify further development of Dendrobium Taiseed Tosnobile dietary products for dry eye relief.

Tri-Service General Hospital

Traditionally, for patients with strabismus and abnormal eye movement, cameras were employed to record the nine different directions of the eye position before-and-after the surgery. The prism diopter measurements described the amount of misalignment of the eyes. However, the eye position measurements readout varied due to poor cooperation of the patient and the inconsistency of examiners’ operation. In addition, some abnormal eye movement diseases are often missed during casual clinical examination due to the small amplitude of ocular position change. Currently, computer can analyze the eye movements by observing the difference in reflection segmentation from the pupil, iris and sclera plus eye position using desktop or hand-held imaging system. This project adopts a new wearable design (a smart goggle recording system), which built by infrared dual-sync camera optical system to do measurements. Compared to other hand-held or desktop devices, our system kept the distance and position to the eyes short; hence, it makes the detection more dynamically accurate under higher resolutions. In addition, the device is comfortable to wear. Therefore, our new smart goggle recording system facilitated the standardized and objective measurements of documentation of the eye movements for patients with strabismus or abnormal eye movements.

Tri-Service General Hospital / Taiwan Innovative Medical Solutions Co., Ltd.

Colorectal cancer has occupied the first place in the incidence of cancer in Taiwan for 12 consecutive years, consistent with the status in Europe and the United States. Colorectal polyps often precursor to cancerous growth, and can be detected and removed by colonoscopy. However, according to the literature, the polyp missed rate of colonoscopy might be up to 20%, which could result in interval cancer after colonoscopic examination.
The GI-CAD Artificial Intelligence Real-Time Detection of Colorectal Polyps is a computer-aided detection system powered by AI. A half million of white light images are used in deep learning and training of GI-CADTM AI models. Our colorectal detection database is of the highest quality and the most versatile in Taiwan. This AI model will detect the suspected colonic lesions on the screen and provide sound alerts to assist endoscopist to improve the polyp detection rate. Meanwhile, Taiwan Innovative Medical Solutions Company also develops edge computing devices suitable for this AI model, which can perform fast and efficient AI inference calculation without network, meeting the real-time information needs of clinical colonoscopy.

Tri-Service General Hospital/Department of Nursing /Nursing Supervisor

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Insulin Injection Memory Pen Cap & Pen

Tzu Chi University of Science and Technology/Research Lab for Agricultural Biomedicine

Our team has conducted an in-depth research on Nostoc commune. We are able to effectively culture a large number of individuals, especially ones spherical in shape (usually found flattened in nature). Its potential uses in health care and skin care products can create novel opportunities in the biomedical industry. Nostoc commune is rich in alginic acid and phycobiliprotein, which makes it a great antioxidant, stimulating cell repair and anti-aging. In addition, Nostoc commune is rich in polysaccharides and fluorescent proteins. The future application of Nostoc commune in solid state fluorescence can further increase its commercial value.

Ultimems, Inc.

Retinal imaging device passes a weak thin laser beam through the pupil, by scanning directly on the retina, high-definition images are provided. A system that once collects light at the center of the iris and projects it onto the retina is called "Maxwellian view". By using a thin laser beam, it is hardly affected by individual differences in lens ability.
This provides excellent focus-freeness. That means the way people see is not affected by their visual acuity. The image looks the same whether you look far or near the quality of the image information obtained from the fundus does not change. So, regardless of visual acuity, the ability of the fundus can be evaluated. Vision training is possible without using visual correction. Because a small device can be used directly over the eyeball, widespread use is expected as a space-saving and inexpensive healthcare device.

Wan Fang Hospital

MoleMe- Skin Mole AI-assisted Risk Determination System