Kaohsiung Medical University

Extracorporeal Optical equipment of precise screw positioning

Low extremity long bone fractures are among the most common fractures encountered in orthopedic practice. They can cause prolonged morbidity and extensive disability, and may be associated with multiple system injuries, especially follow after high-energy trauma events. Intramedullary interlocking nailing and minimal invasive locking plating are considered as the current treatment methods for the management of lower limb long bone fractures.

Free-hand technique of attaining "perfect-circles" with the assistance of fluoroscopy is most common method for the insertion of distal locking screw. Its pitfalls include increased operative time, increased radiation exposure, and the incidence of distal locking screw misplacement.

To solve this problem, a new ideal targeting system should not only be convenient to surgeons to effectively shorten operative duration and lower the chance of screw misplacement, but be cost-effective.
Our invention can provide orthopedic surgeons with a fast, safe, and precise targeting device for screw placement. We use electro-optical engineering to decreased radiation exposure of fluoroscopy to both the surgeons and the patients. This device is easy to learn how to use and can be applied with different brands of nails. This new technique with the targeting device will decrease operative time, decrease the misplacement rate, and decrease the radiation from fluoroscopy during operation for fractures.

Kaohsiung Medical University/Team of Professor Chih-Kuang Wang

The hydrogel hybrid ceramic green body is prepared then passes through the 3D printing method to provide a variety of manufacturing ability, and has a sophisticated stereoscopic structure. This technology also uses the shrinkage characteristics of the negative thermo-responsive hydrogel since the temperature rises, and it has a better sintering and densification process technology to obtain better mechanical properties.

Kaohsiung Municipal Siaogang Hospital

The clinical diagnosis and treatment of patients require laboratory testing of patients’blood, urine or stool samples.These tests are carried out by central laboratories attached to hospitals, which is associated with many disadvantages including limited access for patients in home care and those living in rural/remote areas, patients with chronic diseases in rural areas are often faced with chronic diseases which require frequent monitoring of biochemical and immunological data. Doctors in rural areas also suffer from a lack of proper testing tools; similar situations occur in long-term care facilities or in ambulances where emergency testing is required.
The traditional laboratory spectrometers are characterized by large size and high cost. Recently, using cutting edge optics technology, our research team have developed a micro-spectrometer which greatly reduces the size of a standard laboratory spectrometer into a small microchip (United States patent number 2019/0162883 A1),and it only takes adrop of blood and 10 minutes for the test. When coupled to a membrane-based test strip, this portable micro-spectrometer will be able to perform most laboratory tests, which will replace standard laboratory spectrometers and reduce the need for hospital-based central laboratories. This will enable point-of-care testing for most laboratory tests to be achieved.

Keelung Chang Gung Memorial Hospital

Development and clinical application of novel customized Titanium facial implants

Keelung Chang Gung Memorial Hospital

The application of 3D printing technology for precision craniofacial reconstructive surgery

LanHui Biotech Limited Company

Orchid essence derivatives

Linkou Chang Gung Memorial Hospital

Title: A deep-learning tool for automated measurements after total hip arthroplasty from X-ray: a decision-making assistant system
Summary: The trend for total hip arthroplasty increased as the evolution of the surgical technique and aging population. Hence, the routine follow-up for these patients should also be advanced with the growth. X-ray image is a necessary, quick and convenient diagnostic tool for post-total hip arthroplasty (post-THA) check-up. It can provide lots of information but needs well-experienced surgeon to interpret. Interpretation is extremely time consuming especially for parameters measurements. As a result, the purpose of this novel deep learning (DL) tool is fully automated measurements for post-THR X-ray images with a cost-effectiveness, high reliability and reproducibility.

LuminX Biotech Co., Ltd

A Pharmacokinetic Platform for Preclinical Evaluation of Therapeutic Cells.
LuminX dedicates to accelerate the optimization of cell-therapy-products through specific understanding of therapeutic cells distribution in-vivo, long-term viability, as well as their biological fate either in preclinical or clinical setting, and our technologies can transition a potential therapy from the research stage to advanced clinical and commercial applications to save lives.
Here we can provide:
1. A viable application of LuminX Cell Tracking Kits for background-free imaging and quantitative tracking of therapeutic cells can meet this imperative need.
2. The simplicity of this magnetically modulated fluorescence method, together with LuminX Cell Tracking Kits as well as the large quantity of the nanoparticles taken up by the cells, has permitted studies of the biodistribution and pharmacokinetics of LuminX-labeled therapeutic cells in preclinical evaluation and clinical settings, namely CellCRO platform.
3. The technique is in excellent compatibility with time-gated fluorescence imaging, which have been shown to be a powerful means in acquiring high-contrast fluorescence imaging of LuminX-labeled cells in tissues.
4. The ability to find single therapeutic cells is particularly valuable for ex-vivo histological detection of these cells in clinical trials.
5. This combined approach represents an appealing alternative to hazardous radioisotope labeling techniques in cell therapy applications.

Mass Casualty Incident Management Simulation System

In order to reduce the huge loss of life and property caused by disasters, it depends on the daily disaster drills. The three components of virtual reality technology (1) immersion (2) interaction (3) imagination, introduced into the field of disaster medicine training education. This design is different from other game software. In this software, the voice recognition technology is innovatively added, and the system operator can use the voice mode to control the process by voice. Through the establishment of this system, it can simulate a large number of disaster scenes of disasters. Users can simulate the person in charge of the command. They can use the free angle of view to watch the whole scenes, so as to cultivate command personnel of the mass casualty incident and effectively reduce casualties.

Ming Chi University of Technology/Prof. Jyh-Wei Lee

Coating techniques for endodontic file with high fatigue resistance. This technique produced an amorphous ZrTiB thin film metallic glass (TFMG) with a thickness around several nanometer on the surface of endodontic file. This TFMG is characterized for its very smooth surface, good biocompatible, good adhesion with the substrate and a hardness higher than Ni-Ti alloy, which can effectively prolong the fatigue life of endodontic file higher than 50%. This invention prevents the risk of broken endodontic file. This is a brand-new innovation coating technique in the whole world and is a very practical and full of potential for mass production.