1. Novel polysaccharide nanoparticles as vaccine carrier and adjuvant:
This technology uses polysaccharides such as chitin and fucoidan, which are commonly found in nutritional supplements, and stirs them in a specific ratio at room temperature to form non-toxic nanoparticles (FqC-NPs), which can be recognized by immune cells and are suitable for use as an adjuvant to enhance the protection of vaccines. In addition, we have observed that combining FqC-NPs with anthrax vaccine adsorbed (AVA) significantly increases the magnitude of IgG-anti-protective antigen titers in A/J mice compared to that by CpG oligodeoxynucleotides plus AVA or AVA alone. Furthermore, FqC-NPs plus AVA provided a superior survival rate (100%) of A/J mice.
2. Application of combining unmanned vehicles and FIDO B2 (IBAC) for military biodefense:
The application of unmanned vehicles (Unmanned Aerial Vehicles and Unmanned Ground Vehicles) can expand the energy protection for enabling rapid actions in many aspects of military biodefense.
For various battlefield environments, Institute of Preventive Medicine, National Defense Medical Center has developed a real-time detection and sampling system for air bio-agents that combines unmanned vehicles and FIDO B2 (IBAC), which can perform system monitoring and unmanned sampling.