1. A nucleic acid based lateral flow device for human BK polyomavirus：
BK virus (BKV), a non-enveloped circular double-stranded DNA virus, plays an important role in renal transplantation and water pathogen monitoring. Since it was also listed in the parts of Specific Excreted Pathogens in 2016 Global Water Pathogens Project (GWPP) of United Nations. In this work, a BKV-specific nucleic acid based lateral flow immunoassay is developed for rapid and easily detection of viral DNA within 45 min. The visual signal of detection limit is 10^7 copies/mL. This work provides a promising potential for BKV detection in aquatic environments and clinical application.
2. Mixed reality education and training system：
This system is an object-based educational system that integrates professional knowledge and mixed reality technology. It combines physical and virtual objects through virtual and real superposition of mixed reality, head-up display, and hands-free controller. It simulates the signs and symptoms of the disease, and reflects the situation of history taking, so that users can directly operate the assessment skills in the real world through the mixed reality, and become familiar with the examination skills, to improve the user's practical application and differential diagnosis ability in clinical practice.
3. The cutting-edge optical fiber technology is used in the construction of non-invasive multifunctional physiological real-time detection system：
This study uses the principle of total reflection of optical fiber and no electromagnetic wave to monitor the physiological information of laboratory animals in a non-invasive way, such as changes in respiration, heart rate, etc., to obtain various physiological and behavioral responses of animals infected with the SARS-CoV-2, and it can remotely monitor in real time for 24 hours. In addition, this study also combines AI deep learning to obtain and establish digital basic physiological information of animals as a reference for further studies.