Joy Medical Devices (JMD), a highly R&D-oriented company established at Southern Taiwan Science Park in 2009, is committed to the development of dental and orthopedic biomaterials and related devices by the highest standards in medical device industry. JMD’s technology portfolio covers a series of innovative Ezechbone® products (regular and non-antibiotic antibacterial calcium-based cements and granular bone substitutes), minimally invasive highly porous granule and cement delivery system (jBranchTM), minimally invasive bone cavity creation systems, high strength-modulus ratio titanium alloy, in-situ re-adjustable craniofacial miniplate, smart dental implant, etc. JMD is an ISO 9001, ISO 13485, GMP, MOEA-Certified Biotech and New Pharmaceutical Company. Ezechbone®, developed by a NCKU/JMD joint research project, is an all-synthetic, all-inorganic, highly osteoconductive and fully resorbable calcium-based bone substitute materials. Ezechbone®Granule is a highly porous granular product characterized by its high resorption rate (totally resorbed and replaced by new bone in 3-6 months), while Ezechbone®Cement is featured by its unique non-dispersive behavior upon contact with blood/body fluid without need of any polymeric or other binder additives. The safety and efficacy of these medical devices were confirmed by a series of chemical/physical characterization and biocompatibility tests such as cytotoxicity, sub-chronic toxicity, intracutaneous reactivity, skin sensitization, ocular irritation, endotoxin test, hemolysis test, genotoxicity and implantation. Clinical indications of this series of Ca-based bone substitute materials include sinus lift, ridge augmentation, frontal bone augmentation and treatment for various types of fractures.